MADISON, WI – NOVEMBER 15: A general view of play between the Nebraska Cornhuskers and the Wisconsin Badgers at Camp Randall Stadium on November 15, 2014 in Madison, Wisconsin. (Photo by Ronald Martinez/Getty Images)The biggest game in the Big Ten this weekend is taking place in Madison, Wisc., with No. 15 Wisconsin set to host No. 12 Michigan.The Badgers have suffered a major injury loss prior to Saturday night’s game.Wisconsin star defensive lineman Isaiah Loudermilk has been ruled out for the contest.From 247Sports:Loudermilk, who was seen in a walking boot on Wednesday, has been ruled out for Saturday’s contest.The redshirt sophomore missed the season opener with a leg injury suffered in spring practice. In four games, Loudermilk tallied six tackles, one for loss, and a pass break up.In Loudermilk’s place, UW is expected to use redshirt freshman Matt Henningsen, a former walk-on, and junior David Pfaff, who saw significant snaps last week against Nebraska.Wisconsin and Michigan are set to kick off at 7:30 p.m. E.T.The game will be on ABC.